In April 1774, the frontiersman Michael Cresap was accused of killing two Indians at the mouth of Captina Creek in revenge for the murder of a white trader earlier that month.

[4] There is a plaque located inside a gazebo on the Powhatan Point village fair grounds dedicated to George Washington at the mouth of the creek.

The plaque states that Washington had set camp for a night at the mouth of Captina creek while exploring the Ohio Valley.

The gas industry has a heavy presence in Belmont County, and has caused several spills that may have damaged the ecosystem around Captina Creek.

The surrounding area is also home to many diverse plant life and rare and endangered species such as the bobcat and the Eastern Hellbender.