3FBY131112845ENSG00000105664ENSMUSG00000031849P49747Q9R0G6NM_000095NM_016685NP_000086NP_057894Cartilage oligomeric matrix protein (COMP), also known as thrombospondin-5, is an extracellular matrix (ECM) protein primarily present in cartilage.

[8] It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains.

Binding to other ECM proteins such as collagen appears to depend on divalent cations.

Mutations can cause the osteochondrodysplasias pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).

[9] It is present in high quantities in fibrotic scars and systemic sclerosis, and it appears to have a role in vascular wall remodeling.