Decorin is a small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein.

This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly.

This process is mediated by a high-affinity interaction with VEGFR2 (vascular endothelial growth factor receptor) which leads to increased levels of tumor suppressor gene called PEG3.

[10] Infusion of decorin into experimental rodent spinal cord injuries has been shown to suppress scar formation and promote axon growth.

[11] The decorin-deficient knockout mouse shows reduced inflammatory reactions during contact dermatitis due to a defect in leukocyte recruitment and altered interferon gamma function.