That year, the network introduced Dexter's Laboratory, Cow and Chicken, I Am Weasel, Ed, Edd n Eddy, and Johnny Bravo.

New shows first aired the next year included The Powerpuff Girls, Mike, Lu & Og, and Courage the Cowardly Dog.

In 2001, Cartoon Network continued to air new original programs, such as Sheep in the Big City, Time Squad, and Samurai Jack.

In 2006, several new Cartoon Network originals premiered, including Robotboy, The Life and Times of Juniper Lee, Camp Lazlo, Hi Hi Puffy AmiYumi, My Gym Partner's a Monkey, and Squirrel Boy.

During this time, older programs such as Foster's Home for Imaginary Friends and Camp Lazlo began to air less frequently, in favor of new shows such as Ben 10 and The Secret Saturdays.

In late 2011, Xilam's popular animated series Oggy and the Cockroaches was welcomed into its line-up and adored by the channel, and it still airs due to the said show being one of the network's top-viewed programs.

On January 8, 2022, Cartoon Network Asia, Korea, Hong Kong, and Taiwan rebranded to Redraw your World.

The video series "Craft Your World" will launch on Cartoon Network Asia and Crayola websites and social channels in the coming weeks until the end of 2022.

"Redraw Your World" physical events are also taking place from February onwards in malls across the region, including Singapore, Malaysia and the Philippines.

[4] Cartoonito relaunched as a morning programming block on Cartoon Network Philippines, Asia and Korea on March 28, 2022.

It offers a modern approach to preschool programming, built to support each child’s unique potential with its educational framework called “Humancentric Learning”.

[6] In 2019, Cartoon Network and its sister channel Boomerang ranked first in Mega Manila and National Urban viewership as stated by the gathered data from Kantar Media Philippines.

[7] GMA Network previously broadcast Cow and Chicken, Johnny Bravo, and The Powerpuff Girls in weekday mornings and afternoons in 2001.

Starting July 20, 2020, the block has returned as "Cartoon Network on TV5 Kids" every Monday and Wednesday as part of the broadcaster's programming shuffle.

Programs aired on the said block were The Looney Tunes Show, Rat-A-Tat, Inspector Gadget, The Powerpuff Girls and Mr. Bean: The Animated Series (now on Yey!)

Programs like We Bare Bears, Adventure Time, The Powerpuff Girls & Ben 10 are aired in its original language (English) instead of Filipino.