Casalbuttano ed Uniti (Cremunés: Cazalbütàan) is a comune (municipality) in the Province of Cremona in the Italian region Lombardy, located about 70 kilometres (43 mi) southeast of Milan and about 14 kilometres (9 mi) northwest of Cremona.

Casalbuttano ed Uniti borders the following municipalities: Bordolano, Casalmorano, Castelverde, Castelvisconti, Corte de' Cortesi con Cignone, Olmeneta, Paderno Ponchielli, Pozzaglio ed Uniti.

Casalbuttano has a railway station on the Treviglio–Cremona line.

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