The Cass Farm MPS is a US multiple property submission to the National Register of Historic Places which was approved on December 1, 1997.

[2] Land titles were granted to settle remaining uncertainty over the ownership of some parcels, which was in part due to the then fairly recent departure of British colonial forces.

The rear portion of the ribbon farm changed owners multiple times until Flavius JB Crane purchased it in 1854, when he began platting it.

In the early part of the 19th century, residential growth in Detroit occurred primarily east and west of Woodward, along Fort Street and Jefferson Avenue;[3] the areas near Cass Farm were still predominantly rural in nature.

Streetcar lines established in the 1860s allowed residents to more conveniently travel from the Cass Farm area to downtown.

[2] The period from 1880 to 1895 brought a boom in the construction of elegant single-family and duplex homes in the Cass Farm area.

Cass Farm's proximity to the automotive plants in the Milwaukee Junction area made it ideal for housing auto workers.

[2] Commercial usage also increased in the area, particularly in automotive-related sectors: showrooms, service stations, and part supply businesses.

[2] As the focus shifted to urban rehabilitation in the 1990s, more structures in the area have been refurbished, by Wayne State, other public groups, and by private parties.

The Robert M. and Matilda (Kitch) Grindley House (now unfortunately demolished) was another 19th-century single-family home, dating from the time when the Cass Farm area was still primarily upscale residential.

The Warren-Prentis Historic District is primarily a mix of early private homes and small apartment buildings that moved into the neighborhood around the turn of the 20th century.

Near the same time, increasing infrastructure requirements made the Detroit Edison Company Willis Avenue Station and the Detroit-Columbia Central Office Building necessary for the neighborhood.