Castel di Lucio borders the following municipalities: Geraci Siculo, Mistretta, Nicosia, Pettineo, San Mauro Castelverde.

In ecclesiastical geography, Castel di Lucio is at the far western end of the Roman Catholic Diocese of Patti.

Castel di Lucio was populated in the Norman period by families from continental Italy and southern France.

From 1480 to 1634 there were many lords of Castel di Lucio: Matteo Speciale, Nicola Siracusa, the Lercano, the Ansalone, the Timpanaro, the Cannizzaro, and the Agraz.

In 1726 Francesco Agraz was named first Duke of Castelluzzo in a diploma of Charles IV of Sicily, thus closing the baronial era.