Castile Run is a small tributary to South Fork Tenmile Creek in southwestern Pennsylvania.

The stream rises in northeastern Greene County and flows southeast entering South Fork Tenmile Creek at Chartiers, Pennsylvania.

[4] Castile Run rises at Castile, Pennsylvania,[2] and then flows southeast to join South Fork Tenmile Creek at Chartiers.

[2] Castile Run drains 6.19 square miles (16.0 km2) of area, receives about 40.6 in/year of precipitation, has a wetness index of 306.97 and is about 69% forested.

This article related to a river in Pennsylvania is a stub.