South Fork Tenmile Creek is a 32.10 mi (51.66 km) long 5th order tributary to Tenmile Creek in Greene County, Pennsylvania.

According to the Geographic Names Information System, it has also been known historically as:[1] South Fork Tenmile Creek is formed at the confluence of Claylick Run and Grays Run in Rutan, Pennsylvania,[2] and then flows easterly to join Tenmile Creek at Clarksville.

[3] South Fork Tenmile Creek drains 198.68 square miles (514.6 km2) of area, receives about 41.1 in/year of precipitation, has a wetness index of 298.56 and is about 68% forested.

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