Derek Thompson continued his role as charge nurse Charlie Fairhead and Barbara Marten portrayed sister Eve Montgomery.
[2] Episode one featured four new cast members: Robert Gwilym (clinical director and emergency medicine consultant Max Gallagher);[2] Gerald Kyd (senior house officer Sean Maddox);[3] Jan Anderson (staff nurse Chloe Hill); and Pal Aron (bed manager Adam Osman).
[2] Following a guest stint at the end of the previous series, Cathy Shipton reprised her role as original character Lisa "Duffy" Duffin in episode four.
Michael French and Nicola Stephenson guest appeared in episodes thirteen and seventeen as their Holby City characters, Nick Jordan and Julie Fitzjohn.
A young man, Nick, pretends to be ill so his friends can steal from the hospital, but after they have left he really does feel ill. New nurse Chloe Hill looks after Bonnie (Lorraine Chase), who has a cut face, and finds her hiding in the toilet after her husband Richard shows up.
Guest starring Jacqueline Kington, Ralph Arliss, Lorraine Chase, Bhasker Patel and Shaun Dooley Charlies despatches George to the fire instead.
His mother Louise turns up with Andy; she walked out on her family for him and estranged husband Dave refuses to let her see Joe.
The pedestrian sends Josh and Penny to his flat where his wife is handcuffed to a radiator: She is a heroin addict who has had several miscarriages because of the drugs.
A man is chased through a shopping mall by men he owes money to and pushed off a balcony; the thugs then go to his house and take goods in compensation, terrorising his oblivious wife.
A&E is plagued by a number of minor cases, including two brothers who have playfully stabbed each other, a girl who may have leukaemia, a woman who picked up a tropical disease in India and a man who calls himself the Son of God and says he has cancer of the soul.
Danielle goes to her brother Luke, a drug dealer, for help, while Gina goes to her ex-boyfriend Mick, who she has had charged with rape and who merely gives her another beating.
Chloe helps a difficult patient who has an epileptic fit, while Amy confronts a man taking notes in reception only to learn he is researching a television drama.
He removes the metal from his leg at the hospital in an escape attempt but Max calmly tells him he's bleeding to death and he lets them treat him.
A woman who was bitten by a dog overhears Sean talking about his negligence suit and asks for someone else to treat her; however, he gains her trust by directing Tina to do it.
Duffy, the senior nurse on shift, wants to get rid of him as soon as possible but Max insists on a thorough investigation when it turns out he is being beaten up by drug addicts for his needles.
Pam convinces Mark to give money to a friend of hers to pay a fine but the woman spends it on cocaine instead and ends up being brought in with an overdose.
An older woman having an affair with a married man has an angina attack; her daughter and son-in-law are annoyed that she has an endowment policy in her lover's name but she insists she wants to provide for all the people that she loves.
The police bring in a man dressed as Santa Claus; he tries to escape disguised as surgeon and nearly talks George into letting him go but Charlie stops him.
Frank runs into a friend Alison, who is carrying her newborn baby in a bag and abandons it outside the hospital, where it is found by Duffy and Monica.
Ryan takes Alison, who is having an asthma attack, hostage and asks Eve to drive him to the hospital; he has been on a downward spiral since his wife walked out on the family.
Mark finds an elderly man playing the harmonica in reception and later sees him laying flowers in a cubicle; it is the anniversary of his wife's death.
Guest starring Ian Sharrock, Amelia Lowdell and Louis Morgan Marius is brought in and diagnosed with Crohn's disease.
Max is worried that he doesn't have medical insurance and Eve admits she married him so he could have treatment; he was tortured after being arrested at a civil rights protest.
Residents association leader Simon stirs up a mob to confront local dealer Johnstone, giving him a minor beating before he is arrested.
Kieran's mother Karen arrives with a gun she found in his room and fires into the air, ending the protest; Johnstone and Nicola are rushed to hospital.
Two students argue on a field trip to a zoo and cause their professor to fall from a high tower; at the hospital, he is revealed to be Adam's father Kamal.
Wyvern Tigers' star player turns up hungover but the manager knows there is a scout in the crowd and wants to sell him to raise money.
They change their mind when they learn it simply involves running tests on her blood sample, by which time Max has gone home and George has to miss her son's parents evening to look after things.
The boy is taken away in a second ambulance while Josh and Penny put the girl on a spinal board; however, the floor gives way as they are carrying her out, leaving all three trapped under rubble.
Adam finds a piece of paper Milton left in the photocopier and shows it to Charlie: He has been offered the CEO's job at St Thomas'.