The basilica is a Greek revival structure located at 8th and Plum streets in downtown Cincinnati, Ohio in the United States.

[3] The interior of St. Peter in Chains is distinctly unique among Roman Catholic cathedrals in America, with its Greek-themed mosaics depicting the Stations of the Cross, its ornate Corinthian columns and its massive bronze doors.

In 1938, Archbishop John T. McNicholas moved the archdiocesan seat from St. Peter in Chains to the more modern St. Monica's in the Clifton Heights neighborhood north of downtown.

In the mid-1950s, under Archbishop Karl Joseph Alter's urban-renewal program and in accordance with the city's master plan, St. Peter in Chains underwent significant restoration and expansion.

To date, more than two dozen Roman Catholic bishops have been consecrated within its walls, and the cathedral is a popular venue for weddings, as well as the annual ordination of the archdiocese's priests and deacons.