Caumont-sur-Durance (French pronunciation: [komɔ̃ syʁ dyʁɑ̃s], literally Caumont on Durance; Occitan: Caumont de Durença) is a commune in the Vaucluse department in the Provence-Alpes-Côte d'Azur region of Southeastern France.

The river Calavon flows into the Durance in the commune.

It is home to the Charterhouse of Bonpas (French: Chartreuse de Bonpas), a former Carthusian priory and historic monument.