The district, and therefore the high school's attendance boundary, includes the vast majority of Cape Girardeau, as well as the majority of Dutchtown and small sections of Jackson and Scott City.

The campus has a variety of athletic facilities on site, including a tennis court, a full track, along with baseball, softball, soccer, and marching band practice fields.

A full library is centrally located, indoor courtyard-style, in the academic wing of the building.

Cape Central High School was recognized in May 2007 by ACT as one of 382 schools in America (one of eight in Missouri) for academic rigor in mathematics and science.

Cape Central has also been commended for its Advisory class, which helps many students.