The Chamber of Deputies (Spanish: Cámara de Diputados) is the lower house of the Plurinational Legislative Assembly of Bolivia.

The composition and powers of this house are established in the Political Constitution of the State.

The session room is located in the Legislative Palace building in Plaza Murillo.

The Chamber of Deputies comprises 130 seats (including the seven special seats), elected using a seat linkage based mixed compensatory system using a two votes: 63 deputies are elected by first-preference plurality to represent single-member electoral districts, 60 are elected by closed list party-list proportional representation from party lists on a departmental basis (in districts of varying sizes corresponding to Bolivia's nine departments with a threshold of 3%).

[1] The list seats in each region are awarded proportionally based on the vote for the presidential candidates, subtracting the number of single-member districts won (to provide mixed-member proportional representation).