[2] just south of St. Louis city, on the 43-acre grounds of the motherhouse of the School Sisters of Notre Dame on the Mississippi River.

In 1934 it extended its services to those not aspiring to be religious sisters, and changed its name to Notre Dame High School.

In 1977 with the closing of Notre Dame College on campus the high school acquired that building to house its science, fine arts, and counseling departments.

In 1996 the high school became a part of the newly formed Notre Dame Ministry Corporation.

[4] The school sponsors 13 sports: basketball, softball, soccer, track,[5] field hockey, cross country, golf, tennis, volleyball, swimming, racquetball, cheerleading, and lacrosse.