In 1892, the Congregation arrived in the United States when four Sisters of Sion began educating young children in Auburn and Lewiston, Maine.

For decades to follow, the Sisters continued managing and growing the institution, building their first campus in Kansas City's historic Hyde Park.

[2] The original campus is now Notre Dame de Sion Grade School for Girls and Boys and located at 3823 Locust and the structure was finished in 1927.

Other sports include basketball, softball, cheerleading, swimming, diving, soccer, volleyball, field hockey, lacrosse, cross-country, and track.

Notre Dame de Sion High School received the Community Service Award in 2022–2023.