Charles Edward McDonnell (February 1, 1854 – August 8, 1921) was an American prelate of the Roman Catholic Church.

He was sent to Rome by Cardinal John McCloskey in 1872 to further his studies at the Pontifical North American College.

[5] He erected 54 parishes and schools for new immigrant groups settling in the diocese, many from Italy and Eastern Europe, as well as for Hispanics and African Americans.

Bishop McDonnell adopted the policy of securing members of some order for each of the races and languages in his jurisdiction.

To the institutions of the diocese Bishop McDonnell added two hospitals and largely increased the capacity of one of those already established; the Ozanam Home for Friendless Women; the new St. Vincent's Home for Friendless Boys; two seaside recreation places for children and a trade school farm for orphans.