[13] His double leading off the seventh inning on May 29 ended a perfect game bid by Texas Rangers' starter Martín Pérez.

[15] On June 26, McCormick was optioned to the Triple–A Sugar Land Space Cowboys,[16] but was recalled two days later to replace an injured Michael Brantley.

[20] In Game 1 of the 2022 American League Championship Series (ALCS) versus the New York Yankees, McCormick hit a home run off Clarke Schmidt for the first of his career in the postseason.

[21] McCormick would also hit a go-ahead 2-run home run off of Gerrit Cole in Game 3 of the ALCS en route to an Astros sweep.

In the ninth inning of Game 5 of the World Series, McCormick's catch of a J. T. Realmuto fly ball at the wall at Citizens Bank Park in Philadelphia helped preserve a 3–2 lead for an eventual Astros win.

After colliding with the fence,[22] his landing left a starfish-shaped imprint on the warning track dirt on which the outline of his jersey number 20 was visible.

The Astros defeated the Phillies the following game for their fourth win in the best-of-seven to give McCormick his first career World Series title.

[26] McCormick put together the best month of his career in July, slashing .351/.440/.688 with six home runs and 23 RBIs while posting a 1.128 OPS in 22 games.

[27] Following a weekend series after the All-Star break, July 14–16, 2023, McCormick was named American League (AL) Player of the Week for the first time.

[29] He followed up his career month with his second multi-homer game of the season on August 2 against the Cleveland Guardians, driving in all three Astros runs in a tight 3–2 victory.

[34] After sustaining a fracture in his right hand running out a fly ball versus the Oakland Athletics, he was placed on the 10-day injured list on September 12.