The organic or inorganic substances (e.g., oxygen) used as electron acceptors needed in the catabolic processes of aerobic or anaerobic respiration and fermentation are not taken into account here.
All animals are chemoheterotrophs (meaning they oxidize chemical compounds as a source of energy and carbon), as are fungi, protozoa, and some bacteria.
Some, usually unicellular, organisms can switch between different metabolic modes, for example between photoautotrophy, photoheterotrophy, and chemoheterotrophy in Chroococcales.
[13] Rhodopseudomonas palustris – another example – can grow with or without oxygen, use either light, inorganic or organic compounds for energy.
Even higher plants retained their ability to respire heterotrophically on starch at night which had been synthesised phototrophically during the day.
[8] Some bacteria are limited to only one nutritional group, whereas others are facultative and switch from one mode to the other, depending on the nutrient sources available.
[16] Sulfur-oxidizing, iron, and anammox bacteria as well as methanogens are chemolithoautotrophs, using inorganic energy, electron, and carbon sources.
Chemolithoheterotrophs are rare because heterotrophy implies the availability of organic substrates, which can also serve as easy electron sources, making lithotrophy unnecessary.
Synthetic biology efforts enabled the transformation of the trophic mode of two model microorganisms from heterotrophy to chemoorganoautotrophy: