[4] TPCH has 690 beds and provides around 420,000 episodes of care each year to patients in Queensland and northern New South Wales.

The official opening ceremony was held the next day with the then Queensland Premier Peter Beattie as the chief guest.

[11] In June 2023 Queensland Premier Annastacia Palaszczuk announced a $360 million expansion plan that will add 93 beds to the facility, a new emergency department, and satellite medical imaging, pharmacy and pathology services.

[12][11] The funding also provides for a $60 million boost to deliver two additional operating theatres and a new paediatric outpatient service with 16 treatment spaces at the hospital.

The Queensland Heart Failure and Transplant Unit (QHFTU) and the Indigenous Cardiac Outreach Program (ICOP) are based at The Prince Charles Hospital.

The hospital's echocardiography department organises the Echo Australia conference which is held once a year and has developed techniques related to Numerical Modeling in Echocardiography such as EPLAR (the Echocardiographic Pulmonary to Left Atrial Ratio) and The Relative Atrial Index (RAI).