Later on in life, her parents divorced, she and her mother moved to High Point, North Carolina to help accommodate her with more basketball opportunities.

In 2014, Parker-Tyus transferred to Middle Tennessee State University, where she put up college career-high numbers in scoring and shooting percentage.

The Sky had finished second in the eastern conference with a 21–13 record, but were eliminated 2–1 by the Indiana Fever in the first round.

[2] On July 31, 2018, Parker-Tyus tied her career-high of 20 points with a game winning putback in a 92–91 victory over the Dallas Wings.

[3] Parker-Tyus finished off the season averaging career-highs in every statistical category while playing 34 games with 5 starts.

In 2020, Parker-Tyus would have the best season of her career, putting up new career-high numbers in scoring, assists, rebounds and shooting percentages.

On September 6, 2020, Parker-Tyus scored a new career-high 24 points along with 10 rebounds in a 86–80 loss to the Los Angeles Sparks.

[12] In 2018, Parker-Tyus signed with Bucheon KEB Hana Bank of the South Korean League for the 2018–19 off-season.