The hospital has 229 pediatric beds[1] and is affiliated with the Louisiana State University Health Sciences Center.

The hospital provides comprehensive pediatric specialties and subspecialties to infants, children, teens, and young adults aged 0–21[3][4] throughout New Orleans and the state of Louisiana.

Children's Hospital is operated as a non-profit organization, run by an independent board of trustees.

This facility is located along the levee next to the Mississippi River, near the Audubon Zoo and Audubon Park, New Orleans, on the city's old high ground or "sliver by the river" which escaped the flooding of most of the city in the Levee failures in Greater New Orleans, 2005 in the aftermath of Hurricane Katrina.

Though the hospital received no damage, officials were concerned about the lack of clean water and electricity in the New Orleans area.