The hospital has 496 pediatric beds and is affiliated with the University of Texas Southwestern Medical School.

It provides comprehensive pediatric specialties and subspecialties to infants, children, teens and young adults aged 0–21[2] throughout Texas and surrounding regions.

Children's Health started with just the Dallas location, but has grown to include Children's Medical Center Plano as well as several other pediatric specialty, primary care and urgent care centers located throughout North Texas.

Since 2024, the hospital has been undergoing a $5 Billion expansion, which will move the main building on to campus and adjacent to Clements University Hospital at UT Southwestern in 2031, increasing size and capacity to meet the needs of the rapidly growing population of the DFW metroplex.

[10][11] Children's Medical Center Dallas was ranked 48th in the world among pediatric specialized hospitals in 2024 by Newsweek.