Chloropyridine

Chloropyridines are a group of aryl chlorides consisting of a pyridine ring with chlorine atoms as substituents.

Chloropyridines include: Direct halogenation of pyridine with chlorine gas above 270 °C gives a mixture of 2-chloropyridine and 2,6-dichloropyridine.

[1] 2- and 4-chloropyridine are prepared from the corresponding pyridinols using phosphoryl chloride.

[1] Chloropyridines are important intermediates to pharmaceuticals and agrochemicals.

Reaction of 4-chloropyridine with thioglycolic acid gives pyridylmercaptoacetic acid, a step in the production of cephalosporin antibiotics.