[4] 2-Chloropyridine reacts with nucleophiles to generate pyridine derivatives substituted at the second and fourth carbons on the heterocycle.

Therefore, many reactions using 2-chloropyridine generate mixtures of products which require further workup to isolate the desired isomer.

[2] Some commercial products include pyrithione, pyripropoxyfen, chlorphenamine, and disopyramide.

With the exception of 4-chloropyridine, each of the mono- and di-substituted chloropyridines were found to be relatively resistant to microbiological degradation in soil or liquid media.

2-Chloropyridine exhibits extensive volatilization losses from water, less so when present in soil.