[2] He has since landed roles in television series such as Salamander Guru and The Shadows (2012), To the Beautiful You (2012), Medical Top Team (2013), My First Time (2015), and Hwarang: The Poet Warrior Youth (2016).

Choi was discovered at the SM Casting System in 2006[3] and modeled for Ha Sang-beg's Seoul Collection F/W 08–09 in March 2008.

[15] In 2012, Choi was confirmed to take on the lead role, alongside f(x)'s Sulli and Lee Hyun-woo, in To the Beautiful You, a Korean adaptation of the manga Hana-Kimi.

[20] In December 2012, Choi joined dance project group SM The Performance alongside labelmates from TVXQ, Super Junior, Shinee, and Exo.

[21] Choi began hosting the variety show Mamma Mia in April 2013, but departed after a month due to Shinee's touring schedule.

[26] In August, he participated in the reality series Star Diving Show Splash,[27] but it was cancelled after four episodes after several contestants were injured.

[28] In 2015, Choi was cast as the lead in OnStyle's drama My First Time together with actress Park So-dam, which was broadcast in September.

He was cast in several projects, including a historical Korean drama entitled Hwarang: The Poet Warrior Youth, which began airing on December 19, 2016, on KBS2.

[31] His debut movie project titled Canola, alongside Youn Yuh-jung and Kim Go-eun and directed by Yoon Hong-seung (pseudonym Chang), was filmed in 2015 and released on the big screen in May 2016.

[32][33][34] He was cast in a supporting role in a film entitled The Princess and the Matchmaker, led by Lee Seung-gi and Shim Eun-kyung.

[35][36] Choi was then cast in the movie Derailed alongside veteran actor Ma Dong-seok, which was directed by Lee Seong-tae and premiered at the 2016 Cannes Film Festival.

[40][41] As a result of high online viewer ratings of more than 870,000 views, the web drama was announced to be broadcast on television through JTBC on 8 October.

"[60] He made a special appearance in Yumi's Cells as Chae Woo-gi, the titular character's co-worker and crush.

[68] He embarked on a fan meeting tour in January 2023, beginning at the SM Mall of Asia Arena in the Philippines and continuing on to Taiwan, Hong Kong and Japan.

[69][70] He held his first fan concert, 2024 Best Choi's Minho Fan-Con Multi-Chase, on January 6–7, 2024, at Jangchung Arena in Seoul.

[78] After taking the college admissions test the previous year, he was admitted in 2010 to Konkuk's part-time admittance for the arts and culture film major and graduated in 2015.

His father also added that from the football manager's point of view, he didn't think his son had it in him to make it in that field, stating Minho is a strong-willed person, but has a small frame.

[83] In 2016, Choi was part of UNICEF's "#Imagine" campaign, which was first introduced in November 2014 to commemorate the 25th anniversary of the United Nation's Convention on the Rights of the Child.

[88] In November 2017, Choi together with the First Lady of the United States Melania Trump attended the "Girls Play 2" campaign at the US embassy in Korea, an event organised to promote the 2018 Winter Olympics.

[91] In July 2021, the Korean Professional Football Federation appointed Choi as one of five K-League Ambassadors to help promote the league to the public.

[97] In March 2023, Choi donated 5 million won to Cheongju North Chungcheong Province for the love hometown project.