It is 48 miles 37 chains (78.0 km) down the line from London Paddington and is situated between Goring & Streatley to the east and Didcot Parkway to the west.

The station is managed by Great Western Railway, which operates local services to Didcot Parkway, Oxford, Reading and London Paddington.

On 2 July 1866 Wallingford Road station was renamed Moulsford and the branch to Wallingford was opened five days later;[2] whilst the junction for this was at Moulsford station, the branch line track ran parallel to the main line for nearly 1 mile (1.6 km) before curving away.

In 1892, during quadrupling of the main line, the junction for Wallingford was resited closer to the point of divergence and a new station was built there.

National Rail services at Cholsey are operated by Great Western Railway using Class 387 EMUs.