[1] He attended Highland Springs High School and helped them win consecutive class championships as a junior and senior.
[2] As a true freshman in 2017, Greene played nine games and helped the Dukes be the runner-up in the national championship.
[5][6] He helped James Madison reach another national championship and earned third-team all-conference honors after his 7.5 sacks led all defensive lineman of the Colonial Athletic Association (CAA); he was also selected James Madison's defensive lineman of the year.
[3][7] He led the conference in tackles for loss and was named its co-defensive player of the year, additionally being a first-team All-CAA selection, a finalist for the Buck Buchanan Award as best FCS defensive player, and a first-team All-American by several selectors.
[9] After going unselected in the 2022 NFL draft, Greene signed with the Tampa Bay Buccaneers after a successful tryout.