Sir Christopher Guise, 1st Baronet (died 1670), of Elmore Court in Gloucestershire, England, was a Member of Parliament for Gloucestershire in 1654.
Guise was the son of William Guise of Elmore by his wife Cecilia Dennis, a daughter of John Dennis of Pucklechurch[2] in Gloucestershire.
Guise married firstly Elizabeth Washington, daughter of Sir Lawrence Washington of Garsden, Wiltshire.
He married secondly Rachel Corsellis of a noble Italian family.
He was succeeded by his son Sir John Guise, 2nd Baronet.