[2] Release of pro-inflammatory cytokines and activation of the innate immune system may be the result of either external (biological or chemical agents) or internal (genetic mutations/variations) factors.
[3] Baseline C-reactive protein levels deviate due to natural genetic variation, but significant increases can result from risk factors such as smoking, obesity, lifestyle, and high blood pressure.
[9][10] In severe cases, COVID-19 causes a cytokine storm which contributes to excessive and uncontrolled inflammation of organs, particularly respiratory tissues.
[9][10] Elevated cytokine production alters the innate immune response which leads to abnormal T-cell and B-Cell function that decreases control of viral replication and host defense.
[citation needed] Individuals susceptible to developing chronic systemic inflammation appear to lack proper functioning of Treg cells and TDCs.
In these individuals, a lack of control of inflammatory processes results in multiple chemical and food intolerances, and autoimmune diseases.