The Church of the Ascension is a Catholic parish church in the Archdiocese of New York, located at 221 West 107th Street in the Manhattan Valley section of the Upper West Side of Manhattan, New York City.

The elaborate midblock church, located on 107th Street between Amsterdam Avenue and Broadway, has an attached parish house, both designed in the Sicilian Romanesque of the Norman and Byzantine hybrid style and built between 1896 and 1897 to the designs by the German—American Catholic church-building architectural firm of Schickel & Ditmars.

[1] The parish has a four-storey brick and stone parochial school built by P. J. Brennan & Son, builders, in 1911 to designs by architect F. A. de Meuron of 31 East 27th Street for $120,000.

Around 1900, a used two-manual pipe organ was installed in the Lower Church.

"[1] The church has been the filming location for films and television shows, including Keeping the Faith (2000)[3][better source needed] and as "Trinity Church" in the "Book of Hours" episode from the first season of White Collar (2009).