[1] The building was built in 1852 and is known for its park-like setting in busy Jakarta, and was home to antelope until they were removed in the early 1970s.

The medical center was opened in Gang Pool (near the state palace) on 1 September 1895 as a health service facility.

This funding allowed De Graaf to purchase the mansion which belonged to Raden Saleh in June 1897 and the medical center was transferred from Gang Pool to the newly purchased building.

Cikini Hospital was managed by Repatriation of Allied Prisoners of War and Internees (RAPWI) and eventually by Dienst der Volksgezondheid (DVG).

In 1957, the management of Stichting Medische Voorziening Koningen Emma Ziekenhuis Tjikini was handed over to Indonesian Church Council (Dewan Gereja-gereja di Indonesia - DGI), with Prof. Dr. Joedono as the acting director.