In enzymology, a citrate—CoA ligase (EC 6.2.1.18) is an enzyme that catalyzes the chemical reaction The 3 substrates of this enzyme are ATP, citrate, and CoA, whereas its 3 products are ADP, phosphate, and (3S)-citryl-CoA.
This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases.
The systematic name of this enzyme class is citrate:CoA ligase (ADP-forming).
Other names in common use include citryl-CoA synthetase, citrate:CoA ligase, and citrate thiokinase.
This enzyme participates in citric acid cycle.