[1] He has received two Faust awards, for Daphne by Richard Strauss in 2010, and for Debussy's Pelléas et Mélisande, both at the Oper Frankfurt.

[7] He staged the world premiere of Berio's Cronaca del luogo at the Salzburg Festival in 1999,[8] which is regarded as his international break-through.

[1] Guth directed Verdi's La traviata at the Nationaltheater Mannheim,[5] Otello at the Opernhaus Dortmund, and Stravinsky's The Rake's Progress at the Staatstheater Nürnberg.

[5] At the Staatstheater am Gärtnerplatz, he directed there Lortzing's Der Wildschütz in 1998, recorded for television by Bayerischer Rundfunk.

In 2005, he interpreted Mozart's Lucio Silla for the Wiener Festwochen, played at the Theater an der Wien.

Guth staged Daphne by Richard Strauss at the Oper Frankfurt in 2010, which earned him the award Der Faust.

[24] In November 2012, Guth staged Debussy's Pelléas et Mélisande at the Oper Frankfurt,[1] which earned him the Faust award again.

[26] In 2021, he staged Poulenc's Dialogues des Carmélites at the Oper Frankfurt, conducted by Giedrė Šlekytė.