Within the state, US 41 is paralleled by Interstate 75 (I-75) all the way from Florida to Tennessee, and I-75 has largely supplanted US 41 as a major highway.

The stretch of roadway that carried US 41 until 1982 is now marked as a "county maintained" road and has a weight limit of 56,000 pounds.

At 12th Street, all three routes make a sharp turn to the west while SR 125 branches off in the opposite direction, headed towards Irwinville.

After leaving Tifton, US 41 / SR 7 serves primarily as a secondary parallel route to I-75 through Turner, Crisp, and Dooly counties.

As US 41 / SR 7 approaches Macon from the south it enters Houston County, part of the Warner Robins metro area.

A mile north of there, the highway has another interchange with I-75 which carries the Fall Line Freeway through this part of Macon.

As US 41 now travels north away from the center of the city, Pio Nono Avenue ends at an intersection with US 41 Bus.

Harold G Clarke Parkway ends at the junction and SR 18 joins US 41 as the highway proceeds to the center of Forsyth.

In the seat of Lamar County, Barnesville, US 41 briefly turns to the southwest to meet US 341 at its northern terminus.

To the north of the Barnesville city limits, SR 36 leaves the concurrency travelling northeast towards Jackson.

The concurrency of US 19 / US 41 / SR 3 then proceeds north to the west side of Griffin where it bypasses the center of the city as limited-access highway.

US 19 / US 41 / SR 3 then proceeds through the western tip of Henry County, traveling through Hampton where it is named Bear Creek Boulevard.

In Clayton County, the highway enters the densely commercial and residential southern suburbs of Atlanta.

North of Jonesboro, Tara Boulevard merges directly into I-75 while US 19 / US 41 / SR 3 veers to the north-northeast forming the remainder of a full interchange with the interstate highway.

In Hapeville, the highway serves the northeastern part of Hartsfield–Jackson Atlanta International Airport, passing near the headquarters of Delta Air Lines.

Upon reentering the city limits of Atlanta the concurrency takes the name Metropolitan Parkway as it continues directly north.

Within Downtown Atlanta, US 19 / US 41 / SR 3 runs along Northside Drive where it is joined by US 29 / Georgia Connecting Route 3 (Chapel Street Southwest).

Here the routes run along the west side of the Mercedes-Benz Stadium next door to the Georgia World Congress Center.

The highway briefly curves northeast as it passes over some Norfolk Southern Railway lines, then turns north again at a partial interchange with Tech Parkway Northwest.

US 41 / SR 3 continues north along Northside Drive along the western edge of Atlantic Station towards Buckhead.

Just over a mile north of the river crossing, US 41 / SR 3 leaves Northside Drive, heading northwest towards Marietta.

Directly paralleling I-75, Northside Parkway meets West Paces Ferry Road NW.

Major points as the route enters in Cobb County are Cumberland Mall, an interchange with I-285, Truist Park, and Dobbins Air Reserve Base.

The section that would become US 41 from Echeconnee south through Perry and Valdosta to the border with Florida was paved beginning in 1919 and was later designated as a part of the Dixie Highway in 1924.

After the conclusion of World War II, bypasses were built around the center of many towns and cities along the route, including Acworth, Adairsville, Cartersville, Emerson, Kennesaw, and Marietta.

This caused businesses to vacate the central districts of those municipalities in favor of frontage along the newer routing of the highway.

The bus traveled up an HOV exit ramp and overturned after failing to slow down to negotiate the turn.

[14] The accident caused the National Transportation Safety Board to recommend such HOV exits to be more adequately marked.

[15] US 41 is mentioned in The Allman Brothers Band's song, Ramblin' Man written by Dickey Betts.