[6] This enzyme and redesigned versions of it have been studied as a potential treatment for cocaine addiction in humans.
solution)[8] is being developed under an Investigational New Drug application (IND) for the treatment of cocaine intoxication.
[9] TNX-1300 (formerly known as RBP-8000) is a recombinant protein enzyme produced through rDNA technology in a non-disease-producing strain of E. coli bacteria.
[1][4][10][11] CoCE catalyzes the breakdown of cocaine into metabolite ecgonine methyl ester and benzoic acid.
[9] The enzyme is important in bioremediation, levels of cocaine in European ocean water were cited at 20 ng/L, similar levels in which swollen muscles, and in some cases broken muscle fibers of eels were reported in a controlled study.