[5][15] Meisel shot an editorial of Rocha with Gemma Ward and Amanda Moore, which appeared on the cover of the April 2006 issue of Vogue Italia.

[17] During Paris Fashion Week, she walked for esteemed designers like Stella McCartney, Shiatzy Chen, Christian Lacroix, Emanuel Ungaro, and Marc Jacobs.

A year later, in February 2007, Rocha opened Jean Paul Gaultier's Scottish Highlands-inspired Fall/Winter 2007 show by Irish-dancing down the runway; American Vogue dubbed this the "Coco Moment" and suggested it as a sign that the fashion industry misses the "supermodels".

"[21] In 2008, casting agent James Scully said of Rocha:I will be the first to admit I did not believe the hype, but within five seconds of meeting her, I was totally charmed and understood why everyone loves her.

[22]Rocha has been on the cover of many top fashion magazines including American, Brazilian, Italian, Japanese, Korean, Thai, Mexican and Spanish Vogue, Russian, Australian, Singaporean, Chinese, Vietnamese, Serbian, Thai, Brazilian and Mexican Harper's Bazaar, Flare, Fashion, Numéro, L'Officiel, W, Dazed & Confused, i-D and Time Style & Design, among others.

[23] Since her debut, Rocha has been the face of a variety of advertising campaigns including Versace, Americana Manhasset, Balenciaga, Chanel, D&G, Dior, Dolce & Gabbana, Lanvin, The Gap, Ports 1961, Tommy Hilfiger, Yves Saint Laurent, Esprit, Liz Claiborne, Calvin Klein, Nicole Farhi, DeBeers, Zac Posen, Rimmel, Tatras Japan, Hermès, Fendi, Longchamp, Balmain, Christian Siriano, L'Oréal Paris, Nine West, Chaumet, Akris, Sukeina, Banana Republic, H&M, Dennis Basso, Area, Donna Karan, VDL, NIC ZOE, Senhoa, Diesel, Roberto Bravo and many more.

[4] In July 2010, Rocha appeared on the Vogue website daily for an entire month in a feature named "Today I'm Wearing".

[24] The following month, Rocha appeared on a billboard in Times Square for an ad campaign with Marie Claire magazine in partnership with Project Runway in which she modeled a contestant's winning design.

On October 19, 2011, she appeared as a guest judge on America's Next Top Model, where host and head-judge, Tyra Banks, referred to her as "The Queen of Posing".

In 2015, in the 9th cycle of Australia's Next Top Model, Rocha appeared in the series' ninth episode, where the final four traveled to New York.

She also appeared in season 14 of Project Runway as a guest judge on a challenge where the designers took their inspiration from Finding Neverland on Broadway.

Rocha wrote the foreword to Canadian fashion reporter Jeanne Beker's book Struttin It!, about the modeling profession.

In an open letter to The New York Times on her blog, she wrote, "How can any person justify an aesthetic that reduces a woman or child to an emaciated skeleton?

In her blog, she wrote she hoped the shoot could "balance the scales a little by pulling so far back from what has been the current trend of total digital model manipulation.

To help raise awareness for the cause, Rocha brought in additional models Chanel Iman, Caroline Trentini, and Behati Prinsloo.

[51] On June 16, 2011, Rocha and husband James Conran both received awards for their philanthropic work at the Pay It Fashion Forward event in Manhattan.

[41] Rocha received the Women's Entrepreneurship Day Organization's Fashion Pioneer Award at the United Nations in 2022, celebrating her as a trailblazer and innovator in her field.

[55] Rocha was one of twenty-one high fashion models mentioned in Kanye West's 2010 song "Christian Dior Denim Flow".

She calls herself "a Christian first and a model second", and says that due to her faith she will not pose nude, with cigarettes, nationalistic emblems or religious icons.