The Collège-lycée Ampère (French pronunciation: [kɔlɛʒ lise ɑ̃pɛʁ]) is a school located in the 2nd arrondissement of Lyon.

During the French Revolution, the building was occupied by the troops of the National Convention and renamed École centrale.

Napoléon Bonaparte, then First Consul, was proclaimed President of the Italian Republic during a gathering called the 'consulte de Lyon' in the high chapel of the school and with a consular order of vendémiaire 24 year XI (16 October 1802), the property was transformed into Lycée impérial.

Under the Restoration, it was renamed Collège royal, until the French Revolution of 1848, when it became the Lycée de Lyon.

[citation needed] The chapel of the Trinity also called 'high chapel' was built in the College-lycée Ampère between 1617 and 1622 in the baroque style and the first stone was blessed by archbishop Denis-Simon de Marquemont.