On 23 October 1857, Emperor Napoleon III, by decree, created a regional Consistory, which gathered communities in the departments of Rhone, Loire, Isère, Ain, Jura, Saône-et-Loire and Doubs.

On 24 June 1858, the first regional Chief Rabbi took office and on 5 December of the same year the Consistory received its charter.

On 5 December 1859, the Consistory solicited to Senator and prefect of Lyon Claude-Marius Vaïsse a land to build a synagogue.

On 6 March 1862, Joseph Kippenheim was elected president of the consistory and proposed a temporary place of worship at the Salle des Monnaies.

On 10 December 1943, twenty minutes into the evening worship, as the Lekha Dodi hymn was being recited, two hand grenades were thrown into the synagogue by people who managed to escape by car.

In his testimony of 12 April 1945, Eugene Weill mentioned that when he went to the synagogue on the liberation of Lyon, "the synagogue [is] in a dreadful state, the hall of the temple served as local of drinking militia, the plaques of soldiers killed during the War, served as targets, the Torah scrolls also, there are still sockets on the ground, lamps, chairs and benches have been ransacked, prayer books scattered.

[6] For this, the Consistory, under the chairmanship of Marcel Dreyfus, asked the City of Lyon, as well as other territorial, regional and departmental collectivities.

At the meeting of 14 January 2008, the City Council awarded a grant of 90,197 euro, which corresponded to 50% of roofing and 50% of repairs to the facade on the rue Tilsit.

[7] This resolution was confirmed by the meeting of 23 June 2008, which approved the agreement on objectives and resources and defined the respective obligations of the City of Lyon and the Association of Jewish worship as well as the procedure for granting the subsidy.

[citation needed] A small vestibule, open to the court by three arches, provides access to the prayer room with three wooden doors.