It is a large building with five levels, located next to the Lyon-Perrache railway station which is directly linked by a pedestrian footbridge.

After the railway station opened in June 1857, Perrache became a public transit hub starting from early 20th century, as it became the terminus of many lines of Lyon original tramway network.

On 21 June 2021, the Passage France Pejot has opened, a new way allowing pedestrians and cyclists to pass at ground level under both Perrache Multimodal Hub and railway station, linking Place Carnot and Place des Archives.

On 14 June 2022, the Metropolis of Lyon announced a large renovation project for the whole building of Perrache Multimodal Hub.

[5] The whole complex of Perrache, including both Multimodal Hub and railway station, is seen as an urban barrier between northern and southern parts of the neighbourhood.