It was established in 1994 by Mahidol University under the leadership of Sugree Charoensook [th], the first music school in Thailand.

The popularity of the College of Music in Thailand was spurred by the success of the Thai film Seasons Change.

The program was initially offered at the Institute of Languages and Cultures for Rural Development as an elective course for undergraduate students.

On September 21, 1994, the "College of Music Project" was accepted and acknowledged by Mahidol University.

The "Musica Arboretum" features over 1,500 trees that are used for making musical instruments throughout Southeast Asia.

Prince Mahidol Hall, a 2,000-seat performing arts center that features orchestra, opera, musical theater, and other productions for the benefit of the Mahidol Community and the nation was finished in early 2014 and officially opened in April 2014.

The Southeast Asia Music Museum is an eight-floor building with over 19,000 square meters of space planned, including exhibit space, storage, lecture and seminar rooms, reception areas, and a performance venue.

The library features over 300,000 virtual and physical volumes to support music scholarly study.

Currently the college operates two such campuses at the Seacon Square Srinakarin and Siam Paragon shopping malls.

In addition, the College of Music, Mahidol University hosts over 1,000 performances a year on its campus, including faculty and student recitals, ensemble concerts, workshops and master classes, and other special events.

[8] Source:[9] 2009–2010, Rhinegold Publishing "World Conservatories and International Guide to Music Study".