Many conductors have led the TPO including Gudni Emilsson, Claude Villaret, Delta David Geir, Leo Phillips, Michalis Economou, Jeannine Wagnar, Dariusz Mikulski, Ligia Amadio, Christopher Hughes and Jeffery Meyer.

Soloists from around the world regularly join the TPO for performances and have praised the orchestra for its growth and development in such a short period of time.

Those guests have included Jens Lindemann, Lambis Vassiliadis, Boris Brovtsyn, Alexandros Economou, Tomas Strasil, Reinhold Friedrich, Cristina Bojin, Karina Di Virgilio, Mischa Maisky, Yoon Jin Kim, Jura Margulis, Christopher Espenschied, Dimitry Ashkenazy, Ara Malikian, Serouj Kradjian, Robyn Schulkowsky, Lucia Aliberti, and Otto Schilli among others.

On September 29, 2010, TPO had the distinct honor to give a performance for HM King Bhumibol Adulyadej and HRH Princess Maha Chakri Sirindhorn at Royal Medical College Auditorium, Siriraj Hospital.

Early in 2015, the TPO collaborated with American conductor Jeffery Meyer in its international debut album, recording the complete orchestral works by renowned Thai composer, Narong Prangcharoen.