During its peak, the station become the terminus for the now defunct Pagsanjan Line and consisted of multiple tracks with side and island platforms.

One notable structure was the pebbled pillars made by Filipino Architect and National Artist Pablo Antonio.

On Christmas Day of 1941, a train on the station was bombed by the invading Japanese forces where 30 passengers have lost their lives.

The service uses the CMC Railcars plying the 67 km line, offering fast and cheap mode of transport in the province.

On August 3, 2001, former President Gloria Macapagal Arroyo inaugurated the new Commuter Express (CommEx) service from Tutuban to College using donated 12 Series Passenger Coaches from Japan, which promised development and more opportunities for the Laguna Residents and the province as a whole.

Services was disrupted again five years later, as Typhoon Milenyo as it ravaged the rail line going to Bicol, primarily the San Cristobal Bridge on Calamba on September 28 with Typhoon Reming following two months later, which further damaged theine and destroying Travesia Bridge in Ligao-Guinobatan Section.

The station's passing loop was also in a bad state with some parts of the tracks dismantled, if not being under a layer of soil but still recognizable.

The station was also used by PNR to some extent as it serves as stopover for passing work trains conducting clearing operations in and around Los Banos during the first quarter of the year 2022.

The line utilizes the newest trainsets of PNR bought from PT INKA and will be consisting of only 2 trips daily, departing Lucena early in the morning and Calamba later in the evening.