The company served with the 2nd Massachusetts Infantry in the Santiago (Cuba) Campaign fighting at El Caney and was mustered out of service on 3 November 1898.

In France the company served in all of campaigns of the Yankee Division and was awarded the French Croix de Guerre with Gilt Star for the heroic fight at Apremont on 10–13 April 1918.

The year of training ended in December 1941 but the company's service continued after the Japanese attack on Pearl Harbor brought the United States into the Second World War.

Company B Deployed to Europe with the 104th Infantry Regiment and fought from Normandy across Germany to meet the Soviets in Czechoslovakia at war's end.

In August 2001, the Springfield Rifles now designated as Company A 1-104 IN, headquartered in Agawam MA, mobilized for service in Bosnia-Herzegovina as an element of the NATO Stabilization Force.

(SFOR 10) In September 2005, Company A mobilized as an element of JTF Yankee for rescue and security operations in New Orleans following Hurricane Katrina.

In August 2010, Company A, 1-181 IN deployed for one year of service with the International Security Force in Afghanistan in support of Operation Enduring Freedom.

The company provided command and control for Camp Julien in Kabul and conducted security operations in Kunar, Uruzgan and Kapisa Provinces in Afghanistan.