Anhydrous copper(II) phosphate and a trihydrate are blue solids.

Hydrated copper(II) phosphate precipitates upon addition of a solution of alkali metal phosphate to an aqueous solution of copper(II) sulfate.

[4] The anhydrous material can be produced by a high-temperature (1000 °C) reaction between diammonium phosphate and copper(II) oxide.

Due to it being a copper metal salt it can be used as a fungicide, it works by denaturating proteins and enzymes in cells of pathogens.

[8] It is relatively commonly encountered as the hydrated species Cu2(PO4)OH, which is green and occurs naturally as the mineral libethenite.