[1] The pH of disodium hydrogen phosphate water solution is between 8.0 and 11.0, meaning it is moderately basic: It can be generated by neutralization of phosphoric acid with sodium hydroxide: Industrially It is prepared in a two-step process by treating dicalcium phosphate with sodium bisulfate, which precipitates calcium sulfate:[2] In the second step, the resulting solution of monosodium phosphate is partially neutralized: It is used in conjunction with trisodium phosphate in foods and water softening treatment.

Cream of Wheat to quicken cook time, and Jell-O Instant Pudding for thickening.

In water treatment, it retards calcium scale formation.

[citation needed] It is also found in some detergents and cleaning agents.

[2] Heating solid disodium phosphate gives the useful compound tetrasodium pyrophosphate:[citation needed] Monobasic and dibasic sodium phosphate are used as a saline laxative to treat constipation or to clean the bowel before a colonoscopy.