Along with its sister waterways, the Corrotoman River has important cultural and historical significance in the region due to the pre-colonization of indigenous communities, notably the Powhatan peoples.

Farther north and inland, Corrotoman Point sits on the eastern shore of the river, and Ball Point is located on the western shore of the river.

To the north is Moran Wharf, which signifies the start of the Eastern Branch.

The Merry Point cable ferry is located near the start of the branch that runs between Ottoman Wharf and Merry Point.

The eastern fork ends at Bellwood Swamp, approximately one mile west of Lancaster Courthouse, and the western fork, Little Branch, ends at Griffins Landing.