3N93, 3N95, 3N96139512922ENSG00000106113ENSMUSG00000003476Q13324Q60748NM_001202475NM_001202481NM_001202482NM_001202483NM_001883NM_001288618NM_001288619NM_001288620NM_009953NP_001189404NP_001189410NP_001189411NP_001189412NP_001874NP_001275547NP_001275548NP_001275549NP_034083Corticotropin-releasing hormone receptor 2 (CRHR2) is a protein, also known by the IUPHAR-recommended name CRF2,[5] that is encoded by the CRHR2 gene and occurs on the surfaces of some mammalian cells.

The CRF2 receptor is a multi-pass membrane protein with a transmembrane domain composed of seven helices arranged in a V-shape.

In contrast, CRHR2 alpha contains a unique pseudo signal peptide that is not removed from the mature receptor.

In adenylate cyclase activation assays, CRH-related peptides are 10 times more potent at stimulating CRHR2 beta than CRHR2 alpha and CRHR2 gamma, suggesting that the N-terminal sequence is involved in the ligand-receptor interaction.

[9] This article incorporates text from the United States National Library of Medicine, which is in the public domain.