He ascended the throne in 1487, faced the expansionism of the Aztec Empire and built the city of Guiengola.

The geostrategic importance of the kingdom of Zaachila is due to its condition as a bridge between the highlands of the Anáhuac center and the Mayan lands of what is now Chiapas and Guatemala, as well as its important salt production industry on the coast, goldsmith and grana cochineal (these activities continue to be industries in the region although with less economic influence than in the past) because of this Zaachila was seen under the ambition of the Aztecs.

Zapotec, the city of Huaxyacac was the first to be attacked and destroyed, then it was Mitla, the military campaign spread through the Isthmus of Tehuantepec and reach the Soconusco, this led to Guxi Chikoeza to propose an alliance to the Mixtec king Dzahuindanda, Dzahuindanda accepted this alliance and supplied 24,000 warriors that joined the 36,000 of Zaachila's army, together they succeeded in expelling the Aztecs.

In 1497 Ahuitzotl again attacked the Zapotec and Mixteca allied kingdoms and sent the general command army Tlacatecat to the bastion that represented Guiengola, the siege of the city lasted 7 months.

Ahuitzotl then proposed a peace treaty to Guxi Chikoeza in which he included the hand of his daughter, the princess Xilabela.