Non-menthol throat lozenges generally use either zinc gluconate glycine or pectin as an oral demulcent.
[1] Candies to soothe the throat date back to 1000 BC in Egypt's Twentieth Dynasty, when they were made from honey flavored with citrus, herbs, and spices.
[citation needed] In the 19th century, physicians discovered morphine and heroin, which suppress coughing at its source—the brain.
Popular formulations of that era included Smith Brothers Cough Drops, first advertised in 1852, and Luden's, created in 1879.
Concern over the risk of opioid dependence led to the development of alternative medications.